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Despite superior binding to plasma proteins (98-ninety nine%) - generally albumin and to a lesser extent α1-acid glycoprotein - diazepam is commonly dispersed into tissues and crosses the blood-brain barrier and is very lipid soluble, which leads to the Preliminary consequences to lower promptly as it is redistributed into Unwanted fat deposits an
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Metabolites of the drug are acknowledged being substantially excreted because of the kidney, and the risk of poisonous reactions can be better in patients with impaired renal perform . Due to the fact elderly patients are more likely to have reduced renal purpose, treatment need to be taken in dose choice, and it might be beneficial to observe rena